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Imaging distribution radiolabeled

Scintigraphic imaging is a noninvasive imaging technique commonly applied in nuclear medicine. Radiolabeled compounds (called radiopharmaceuticals or radiotracers) are administered intravenously to patients for diagnostic or, in certain cases, therapeutic purposes. The in vivo distribution can provide important physiological information about tissue function. [Pg.170]

PET offers the possibility to quantitatively measure the myocardial blood flow (MBF). MBF tracers can be divided into two groups. The first group is freely diffusible and represented by [ 0]H20. These tracers do not show any specific absorption and their distribution is completely determined by diffusion. Consequently, the measurement of the MBF is based on the first-pass extraction and clearance data. Because of the low heart-to-blood radioactivity ratio, the freely diffusible tracers provide myocardial images with low signal-to-background ratios. The second class is composed of highly extractable heart tracers. The tracer p NjNHs belongs to this family. These radiolabeled compounds are characterized by a selective extraction and retention in the myocardium. The... [Pg.96]

One of the most significant medical applications of radiolabelled compounds is for PET scans. These are important diagnostic and research tools that can be used to study the distribution of drugs or biomolecules in the body, and for imaging of organs. [Pg.617]

Figure 8 Representative autoradiographic images taken from cross sections of rabbit eyes injected intravitreously with radiolabeled INS37217 (3H-INS37217 at 3 mg per eye) showing the distribution of radiolabeled signal in various ocular structures at the postinjection time points indicated. Radioactivity from INS37217 or its metabolites is distributed throughout the entire vitreous within 15 minutes and is largely absent by 48 hours. Figure 8 Representative autoradiographic images taken from cross sections of rabbit eyes injected intravitreously with radiolabeled INS37217 (3H-INS37217 at 3 mg per eye) showing the distribution of radiolabeled signal in various ocular structures at the postinjection time points indicated. Radioactivity from INS37217 or its metabolites is distributed throughout the entire vitreous within 15 minutes and is largely absent by 48 hours.
Fig. 5.4 Distribution of radiolabeled drugs in humans monitored by PET. (a) A brain image of ["CJtemozolomide, showing high localization of radioactivity in the tumor (glioma), (b) A thoracic image of [ C]DACA scan, showing localization in the myocardium and tumor (mesothelioma). Fig. 5.4 Distribution of radiolabeled drugs in humans monitored by PET. (a) A brain image of ["CJtemozolomide, showing high localization of radioactivity in the tumor (glioma), (b) A thoracic image of [ C]DACA scan, showing localization in the myocardium and tumor (mesothelioma).
The labeling of WBC with Tc chelates, in particular HMPAO dramatically increased the widespread availability and use of these studies in nuclear medicine. Several clinical applications of radiolabeled WBC exist (Table 8.6), but the main clinical indication of imaging WBC distribution has been the detection of inflammatory bowel disease. [Pg.117]

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