Icosanoid

Prostaglandins belong to a group of compounds that because they are related to icosanoic acid [CH3(CH2)i8C02H)] are collectively known as icosanoids The other icosanoids are thromboxanes prostacyclins and leukotrienes... 

Older versions of the lUPAC rules called the unbranched carboxylic acid with 20 car bon atoms e/cosano/c aad Consequently icosanoids are often referred to as eicosanoids... 

Icosanoids (Section 26 6) A group of naturally occurring com pounds derived from unsaturated C20 carboxylic acids Imide (Section 20 16) Compound of the type... 

Bemart, M. and Gerwick, W. H., Isolation of 12-(S)-hepe from red alga Murrayella periclados and the structure of icosanoid from Laurencia hybrida. Implications to the synthesis of hybridolactone, Tetrahedron Lett., 29, 2015, 1988. 

Eicosanoids, also referred to as icosanoids, are so named because of the 20-carbon constituency that identifies this class of oxygenated lipid molecules. A primary synthetic pathway for these molecules involves the phospholipase-mediated cleavage of a membrane phospholipid to produce arachidonic acid [(all-Z)-ik osa-5,8,ll,14-tetraenoic acid]. From this biologically essential intermediate fatty acid, two major subclasses of eicosanoids can be produced 1) leukotrienes, via the action of lipooxygenases, and 2) prostanoids, via the action of cyclooxygenases (COX-1 and COX-2). Examples of chemical structures for a leukotriene (Fig. la) and three types of prostanoids (Fig. Ib-d) underscore their shared arachidonate origin. 

Thaler-Don. II.. dcPaulet. A. C.. and Paolelli. R. Icosanoids and Cancer. New York. Raven Press. 19X4. 

Lefer AM, Stahl GL, Lefer DJ, Brezinski ME, Nicolaou KC, Veale CA, Abe Y, Smith JB Lipoxins A4 and B4 Comparison of icosanoids having bronchoconstrictor and vasodilator actions but lacking platelet aggregatory activity. Proc Natl Acad Sci USA 1988 85 8340-8344. 

Icosanoids A group of naturally occurring compounds derived from unsaturated C20 carboxylic acids. 

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