Hypothesis temperature affect modeling

Conc ttmtion Residuals vs. Other Postulated Vanable Plot (Model and Sample Die ostic) It can be helpful to plot the concentration residuals versus anotherparaineter that is postulated to be important. For example, it may be suspected that the order in which the samples were run has an effect on the concenfeation errors due to changes in the room temperature. Without the a priori infcEmation or hypothesis, these dependencies can go undiscovered, because the patterns appear only when the x axis represents a variable that is affecting pisiictions. 

The investigations carried out by Professor French and his students were based on sound experimental approaches and on intuitive theoretical considerations. The latter often resulted in new experiments for testing a hypothesis. On the basis of theoretical considerations, Professor French proposed a model for the structure of the amylopectin molecule, and the distribution of the linear chains in this molecule. This model was tested by utilizing enzymes that selectively cleave the linear chains, and the results substantiated the theoretical deductions. He proposed a theory on the nature and types of reactions occurring in the formation of the enzyme - starch complex during the hydrolysis of starch by amylases. In this theory, the idea of multiple attack per single encounter of enzyme with substrate was advanced. The theory has been supported by results from several types of experiments on the hydrolysis of starch with human salivary and porcine pancreatic amylases. The rates of formation of products, and the nature of the products of the action of amylase on starch, were determined at reaction conditions of unfavorable pH, elevated temperatures, and increased viscosity. The nature of the products was found to be dramatically affected by the conditions utilized for the enzymic hydrolysis, and could be accounted for by the theory of the multiple attack per single encounter of substrate and enzyme. 

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