Time window hypothermia

The neuroprotective effects of other compounds have also been demonstrated to be enhanced when combined with hypothermia. Guan et al. (6) evaluated the efficacy of hypothermia in combination with insulinlike growth factor (IGF) using a modified Levine hypoxic-ischemic model (right carotid ligation plus 10 min of hypoxia in neonatal animals). In this study, the use of hypothermia resulted in a significant extension of the therapeutic time window. Recovery in a cool vs a warm environment (23 C vs 31 C) extended the effectiveness of IGF-1 by up to 4 h. 

Several animal models suggest that the time to initiate cooling following TBI is brief. Some rat models suggest that the therapeutic window for treatment with hypothermia is approx 25 min (41,42). These data would seem quite discouraging, as most traumatic brain injury patients do not arrive at the hospital and receive complete evaluation until significantly more time has elapsed. Even with rapid transporta-... 

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