Hypertension in pregnancy

Antihypertensives for hypertension in pregnancy are Pi-selective adrenoceptor-blockers, methyldopa (p. 96), and dihydralazine (i.v. infusion) for eclampsia (massive rise in blood pressure with CNS symptoms). 

Konianim. C, and A.L. Tranquilli Calcium Antagonists in Ihe Treatment of Hypertension in Pregnancy. Parthenon Publishing Croup. New York. NY. 1999. 

Lesny P, Maguiness SD, Hay DM, Robinson J, Clarke CE, Killick SR. Ovarian hyperstimulation syndrome and benign intracranial hypertension in pregnancy after in-vitro fertilization and embryo transfer case report. Hum Reprod 1999 14(8) 1953-5. 

Two infants with featnres of severe beta-blockade (bradycardia, persistent hjrpotension), persistent hypoglycemia, pericardial effnsion, and myocardial hjrper-trophy were born before term to mothers taking long-term oral labetalol for hypertension in pregnancy. 

Lowe SA, Rubin PC. The pharmacological management of hypertension in pregnancy. J Hypertens 1992 10(3) 201-7. 

Friedman EA, Neff RK. Pregnancy outcome as related to hyperteusiou, edema and proteinuria, lu Hypertension in Pregnancy. New York John Whey and Sons, 1976. 

Zuspan FP, Zuspan KJ, Wilson AL. Acute and chronic hypertension in pregnancy. In Rayburn WF, Zuspan FP, editors. Drug Therapy in Obstetrics and Gynecology. Norwalk, CT Appleton-Century-Crofts, 1982 65. 

Pregnant women taking beta-blockers for hypertension in pregnancy should not be given indometacin, as it can raise the blood pressure (47). 

Two women with pre-eclampsia treated with pindolol and propranolol became extremely hypertensive when indometacin was added for premature contractions (47). Pregnant women taking beta-blockers for hypertension in pregnancy should not be given indometacin, as it can raise the blood pressure (47). 

Papatsonis DN, Lok CA, Bos JM, Geijn HP, Dekker GA. Calcium channel blockers in the management of preterm labor and hypertension in pregnancy. Eur J Obstet Gynecol Reprod Biol 2001 97(2) 122-40. 

Many agents can be used to treat chronic hypertension in pregnancy (Table 13-7). Methyldopa is considered the drug of choice. Data indicate that uteroplacental blood flow and fetal hemodynamics are stable with methyldopa. Moreover, it is viewed as very safe based on long-term follow-up data (7.5 years) that have not demonstrated adverse effects on childhood development. /S-Blockers, labetalol, and... 

Nondrug therapeutic approaches for hypertension in pregnancy traditionally have focused on activity restriction, psychosocial therapy, and biofeedback. There is currently no evidence that any of these approaches improves pregnancy outcome, and prolonged bed rest may increase a pregnant woman s risk of venous thromboembolic disease. 

Methyldopa (Aldomet) is a centrally acting antihypertensive agent. It is a prodrug that exerts its antihypertensive action via an active metabolite. Although used frequently as an antihypertensive agent in the past, methyldopa s significant adverse effects limit its current use in the United States to treatment of hypertension in pregnancy, where it has a record for safety. 

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