Hypertension genetic factors

Sodium and Hypertension. Salt-free or low salt diets often are prescribed for hypertensive patients (57). However, sodium chloride increases the blood pressure in some individuals but not in others. Conversely, restriction of dietary NaCl lowers the blood pressure of some hypertensives, but not of others. Genetic factors and other nutrients, eg, Ca " and K", may be involved. The optimal intakes of Na" and K" remain to be estabUshed... 

Currently, research in the pharmaceutical industry is concentrated on about 100 diseases that in their opinion really matter. In order to calculate how many targets may refer to these diseases of interest the following is estimated from diseases with well understood pathways such as diabetes type II and hypertension [3] Most diseases are caused by genetic factors, and proved to be multifactorial. The number of genes involved to contribute to the various disease phenotypes turned out to be around five to ten, thus resulting in 500 to 1,000... 

Hyperlipidemia Hypertension Smoking yfDUVJ Diabetes IUl 1 Male gender Obesity Sedentary lifestyle Stress (type A personality) Elevated homocysteine Oral contraceptive use Increasing age Familial/genetic factors... 

Yamori, Y, Ooshima, A., and Okamoto, K. (1972) Genetic factors involved in spontaneous hypertension in rats an analysis of F 2 segregate generation. Jpn. Circ. J. 36,561-568. 

Hypertension is a strong risk factor predisposing individuals to cardiovascular disease with the strength of the association being virtually unaffected by age. However, as yet, it is difficult to decide whether hypertension and its haemodynamic consequences per se are contributory or whether it is other environmental or genetic factors with which it is associated that are more significant. 

Hypertension is one of the two principal risk factors of many cardiovascular diseases, such as coronary heart disease (CHD), stroke, and CHF. Individuals are considered hypertensive if their systoHc arterial blood pressure is over 140 mm Hg (18.7 Pa) or their diastoHc arterial blood pressure is over 90 mm Hg (12 Pa). Over 60 million people, or one-third of the adult population in the United States are estimated to be hypertensive (163). About 90% of these patients are classified as primary or essential hypertensive because the etiology of their hypertension is unknown. It is generally agreed that there is a very strong genetic or hereditary component to this disease. 

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