Hyoscine injection

Hyoscine Injection (Hyoscine hydrobromide). UCB Pharma Ltd UK Summary of product characteristics, June 2005. 

Antlspasmodic 2 to 3 mg/kg/day divided every 4 to 6 hours and at bedtime. SCOPOLAMINE HBr (Hyoscine HBr) Give subcutaneously or IM may give IV after dilution with Sterile Water for Injection. 

Hyoscine butylbromide (strictly N-butylhyosdne bromide, Buscopan) also blocks autonomic ganglia. If injected, it is an effective relaxant of smooth muscle, including the cardia in achalasia, the pyloric antral region and the colon, which properties are utilised by radiologists and endoscopists. It may sometimes be useful for colic. 

Scopolamine (hyoscine N-butylbromide) is available as an antispasmodic product (20 mg ampule for injection and 20 mg tablets) for use in humans. In addition, there is a veterinary product that contains scopolamine and dipyrone approved for use as an antispasmodic/analgesic in animals. In addition to blocking the effects of acetylcholine at the muscarinic receptor, scopolamine affects nicotinic receptors in intestinal ganglia and does not affect the CNS. In horses, scopolamine is used as an antispasmodic and to relax the rectum to facilitate abdominal palpation. In one report, 0.2 mg/kg was as effective as 0.2 mg/kg scopolamine plus 2.5 mg/kg dipyrone in relieving discomfort caused by balloon dilatation of the cecum (Roelvink et al 1991). The analgesic effect tasted for 20 min. 

Injection of Hyoscine Hydrobromide, B.P, Usually contains 0 04 per cent. 

Fig. 11.16. a Undistended stomach the air-filled contour is seen below the costal margin (forceps) and the colon outlined by barium given the night before (C). Arrow Needle from local anaesthetic injection, b After administration of hyoscine bromide and insufflation of 1000 ml air the stomach is well distended, displacing the colon and approximating the anterior abdominal wall... 

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