Hymenocallis littoralis

Hymenocallis littoralis (spider lily) (Amaryllidaceae) [bulb] cf. trans- [1,1 Ob] Dihydronarciclasine (= fr[Pg.353]

Hymenocallis littoralis (spider lily) (Amaryllidaceae) [bulb]... 

The cytotoxic alkaloid 7-deoxy-fmns-dihydronarciclasine (279) was isolated from the bulbs of Hymenocallis littoralis, Hymenocallis caribea, and Hymenocallis latifolia by Pettit et al. in 1993 (253). Recently, Kadas and co-workers employed an iminium-catalyzed Michael addition between 278 and acceptor 280 to obtain the... 

The Amaryllidaceae alkaloids are restricted to the monocot family that coined their name. They are derived from one molecule of tyrosine and protocatechuic aldehyde, which originates from phenylalanine. The central intermediate of their biosynthetic pathway is norbelladine. Nearly 500 structures of Amaryllidaceae alkaloids are known, and some of them possess significant pharmacological activities (Jin, 2007) (Fig. 10). For example, the isocarbostyrils pancratistatin from the spider lily Hymenocallis littoralis) and narciclasine from Narcissus species show promising antineoplastic properties (Dumont et al., 2007 McLachlan et al, 2005). Lycorine that occurs, e.g., in Clivia, Crinum and Galanthus... 

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