Hydroxyphosphonic acids chiral

The reduction of yff-ketoesters to aldols is one of the most important applications of Ru(II)-BlNAP catalysts [7]. As a special bonus, the chirally labile C2 stereogenic center can be exploited in a dynamic kinetic resolution such that racemic reactants yield only one of the four conceivable stereoisomers in high diastereomeric and enantiomeric excess. This strategy has been extended to the reduction of -ketophosphonates 10. The 3-hydroxyphosphonic acids 7 which are accessible by this route constitute promising starting materials for the synthesis of peptide analog and antibiotics [8]. 

---