4- hydroxymethyl-2-octyl

The OBO ester (2,6,7-trioxabicyclo[2.2.2]octyl ester) can also be prepared from a secondary or tertiary amide (Tf20, CH2CI2, Pyr then 2,2-bis(hydroxymethyl)-l-propanol, 10-88% yield). ... 

FIGURE 3 Effect of the amount of cholesterol on the particle size. Phosphatidylcholine/cholesterol liposomes were prepared by the octyl glucoside dilution technique. The begin concentration of the mixed micelles was 150 mM octyl glucoside and 10 mM phosphatidylcholine in 10 mM tris(hydroxymethyl)aminomethane and 0.9% NaCl, pH 7.4. Dilution was performed with an automatic titration unit at a dilution rate (= dilution factor, relative to the initial volume, per unit of time) of 0.026 sec"l ( a and ) or 0.69 sec l ( and o). Mean diameters after dilution and ) and after filtration ( L and q) are repi sented. (Adapted from Jiskoot et al, 1986a.)... 

Reduction of isoanacardic aldehyde gave a methylol which could also be synthesised directly from cardanol together with formation of some of the 4,6-bis-methylol. The monomethylol compound isoanacardic alcohol was an effective solvent extractant for the borate anion (ref. 279, 293). The isomeric compound, anacardic alcohol (ref. 88) was similarly obtained from anacardic acid (ref. 180). This In conjunction with the teriary amine Aliquat 336 was highly effective for the solvent extraction of the borate anion (ref. 293). Both these substances were comparable in properties to the 2,6-bis(hydroxymethyl) derivatives of 4-t nonylphenol and to 4-t octyl-2-chloro-6-hydroxymethylphenol (ref. 294). 

Ethylparaben Hexahydro-1,3,5-triethyl-s-triazine 2[(-Hydroxymethyl) amino] ethanol Methylparaben 2-n-Octyl-4-isothiazolin-3-one Sodium o-phenylphenate 2,2 -Thiobis (4-chlorophenol) Tris (hydroxymethyl) nitromethane Zinc pyrithione biocide, latex paints... 

BFg-etherate soln. added to a mixture of 3a,21-dihydroxy-11-0x0-20,20-bis-(hydroxymethyl)-5y -pregnane, ethyl orthoformate, and dioxane, stirred 40 min. at 25°, then neutralized with pyridine and NaHGOg 3a-hydroxy-ll-oxo-17j -(3, 5, 8 -trioxabicyclo [2.2.2] octyl)-5/ -androstane. Y ca. 100%.—The formation of the trioxabicyclooctane serves as a means of protecting the three methylol groups simultaneously, while the 3a-hydroxy group is undergoing transformation. D. Bertin and L. Nedelec, Bl. 1962, 1555. 

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