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Hydroxyl, functional groups, glucuronic acid conjugates

Two phases can be distinguished in the pathways of biotransformation. Phase I involves addition of functionally reactive groups by oxidation, reduction or hydrolysis. Phase II consists of conjugation of reactive groups, present either in the parent molecule or after phase I transformation. Phenytoin, for example, is first hydroxylated by a phase I reaction and subsequently conjugated with glucuronic acid. The various phase I and phase II reactions are summarized in Tables 30.3 and 30.5. [Pg.509]

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See also in sourсe #XX -- [ Pg.9 ]



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Acidic function

Acidic functional groups

Acidic functionalities

Acidity functions

Conjugate functions

Conjugate hydroxylation

Functional groups conjugation

Glucuronate

Glucuronate/glucuronic acid

Glucuronates

Glucurone

Glucuronic

Glucuronic acid conjugates

Glucuronic acid conjugation

Hydroxyl acids

Hydroxyl functional groups

Hydroxyl functionalities

Hydroxyl functions

Hydroxyl group function

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