Hydroxyapatite laminine

Fig. 11.22 Preparation of hydroxyapatite-laminine nano-hybrid layer.

No percutaneous devices are completely satisfactory. Nevertheless, some researchers believe that hydroxyapatite maybe part of a successful approach. In one experimental trial, a hydroxyapatite-based percutaneous device was associated with less epidermal downgrowth (1 mm after 17 months vs. 4.6 mm after 3 months) when compared with a sUicone rubber control specimen in the dorsal skin of canines. Researchers have also investigated coatings such as laminin-5 which has been shown to enhance epithelial attachment. 

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