7-Hydroxyalkylphosphonium salts, synthesis

Synthesis and reactions of oxaphospholanes using hydroxyalkylphosphonium salts 00YGK548. 

A general synthesis of 2-, 3-, and 4-hydroxyalkylphosphonium salts (137) is provided by the reactions of triphenylphosphine with cyclic ethers in the presence of strong acids.Dialkyldiphenyl-... 

Preparation.—Conventional quaternization reactions of phosphines with alkyl halides have been used for the preparation of chiral P-hydroxyalkylphosphonium salts for use in prostaglandin synthesis and of the salts (111), (112), and (113). This approach has also been used for the preparation of polymer-bound phosphonium salts for use in subsequent Wittig reactions and of a range of co-dialkylaminoalkylphosphonium salts. The salt (114), of limited thermal stability, is formed on treatment of the parent phenylphosphaferrocenophane (67, R = Ph) with iodomethane. The oxonium salt (115) is converted into the mixed onium salt (116) on treatment with triphenylphosphine. A range of... 

---