4- hydroxyacetophenone monooxygenase

Figure 3 Illustration of overlapping substrate specificities of four BVMOs. Cyclohexanone monooxygenase (CHMO), cyclopentanone monooxygenase (CPMO), 4-hydroxyacetophenone monooxygenase (HAPMO) and phenylacetone monooxygenase (PAMO). For each enzyme, several typical substrates are...

Kamerbeek NM, All Olsthoorn, MW Fraaije, DB Janssen (2003) Substrate specificity and enantioselectivity of 4-hydroxyacetophenone monooxygenase. Appl Environ Microbiol 69 419-426. 

More recently, Jansen and coworkers [90] used 4-hydroxyacetophenone monooxygenase (HAPMO) for aerobic oxidation of sulfides. Interestingly, both PhSMe and p-MeC6H4SMe gave the corresponding sulfoxides in >99% ee, which should be compared with the 99 and 37% ee, respectively, obtained with CHMO [86]. The flavoenzyme HAPMO, which has been cloned [90, 91], is a promising biocatalyst for enantioselective oxidation of sulfides to sulfoxides. 

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