Hydroxy-tetrahydro-imidazole

Die Reduktion kann bis zum 3-Oxo(Thiono)-5,6-diphenyl-hexahydro-l,2,4-triazin weitergeftihrt werden, dabei wird jedoch beim 3-Oxo-tetrahydro-Derivat in Acetonitril bei pH — 1 (-1,0 V) unter Ringverengung das 2-Hydroxy-4,5-diphenyl-imidazol (50% d.Th. F 318°) gebildet. Zur Reduktion der N-Alkyl-l,2,4-triazinone s, S. 613. 

H-Purin und 6-Amino-purin (unter Ammoniak-Abspaltung) liefern in waBrigen Puf-ferlosungen an Quecksilber l,2,3,6-Tetrahydro-9H-purin, das zu 5-Amino-4-(hydroxy-methylamino-methyl)-imidazol hydrolysiert werden kann2. 

To a solution of 350 mg of methyl 4-[2-endo-hydroxy-l-exo-hydroxymethyl-3a,8b-cis-2,3,3a,8b-tetrahydro-lH-5-cyclopenta[b]benzofranyl]butyrate in 3.5 ml of anhydrous dimethylformamide cooled in an ice bath were added 140 mg of imidazole and 360 mg of t-butyldimethylsilyl chloride, and after the mixture was stirred for 3 hours at room temperature, dimethylformamide was removed under reduced pressure. The residue was dissolved in a mixture of 10 ml of acetic anhydride and 5 ml of pyridine. After the mixture was stirred for 2 hours at room temperature, the reaction mixture was concentrated. 

Imidazo [2,l-a]isoqninolines, 2,3,5,6-tetrahydro-6-hydroxy-17, 889 suppl. 26 Imidazole... 

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