3- Hydroxy-6-methylpyridine

Vitamin B6 (Fig. 1) is the collective name for all 3-hydroxy-2-methylpyridine-derivatives with vitamin... 

This enzyme [EC 4.1.1.51] catalyzes the conversion of 3-hydroxy-2-methylpyridine-4,5-dicarboxylate to 3-hy-... 

This FAD-dependent enzyme [EC 1.14.12.4], also known as 3-hydroxy-2-methylpyridinecarboxylate dioxygenase, catalyzes the reaction of 3-hydroxy-2-methylpyridine-5-carboxylate with NAD(P)H and dioxygen to produce 2-(acetamidomethylene)succinate and NAD(P)+. 

Finally, compound (iv) is condensed with either trimethyl(6-methyl-3-pyridyl)tin or the boronate ester by means of Pd(PPh3)4 to afford etoricoxib. The metallated pyridine (vii) is obtained by esterification of 3-hydroxy-2-methylpyridine with triflic anhydride to give the corresponding triflate, which is treated with a tin reagent to yield the target tin intermediate. The boron lithium salt (viii) is prepared by treatment of 5-bromo-2-methylpyridine with butyllithium followed by addition of triisopropyl borate. 

Pathways C and D are less well documented, mainly because oxazoles lacking a 5-alkoxy substituent show reduced reactivity towards the usual dienophiles. An example of reaction C is the formation of 3-hydroxy-2-methylpyridine from 4-methyloxazole and acrylonitrile (equation 13). Dehydrogenation (path D) is rare but proceeds in the presence of a hydride acceptor. Thus 4-methyloxazole reacts with ethyl acrylate in the presence of hydrogen peroxide to give ethyl 3-hydroxy-2-methylpyridine-5-carboxylate in 27% yield (equation 14). 

Hydroxy-2-methylpyridine-4,5-dicarboxylic acid (2-methyl-3- 79FL... 

N,N-Dimethyloleyl N-oxide. See Oleamine oxide Dimethylolglyoxalurea. See Dimethyloldihydroxyethyleneurea 1,3-Dimethylolhexahydro-2-pyrimidone. See Dimethylolpropylene urea 4,5-Dimethylol-3-hydroxy-2-methylpyridine. See Pyridoxine... 

CAS 65-23-6 EINECS/ELINCS 200-603-0 Synonyms 4,5-Bis-hydroxymethyl-2-methyl pyri di n-3-ol 4,5-Di methylol-3-hydroxy-2-methylpyridine 3-Hydroxy-4,5-dimethylol-o-picoline 5-Hydroxy-6-methyl-3,4-pyridinedimethanol 3-Hydroxy-2-picoline-4,5-dimethanol... 

The generic term vitamin Be refers to all 3-hydroxy-2-methylpyridine derivatives that exhibit the biological activity of pyridoxine in rats (7). Pyridoxine (3-hydroxy-4,5-bis-(hydroxymethyl)-2-methyl pyridine) should not be used as generic term synonymous with vitamin B. Two other forms of vitamin Be, pyridoxal (PL) and pyridoxamine (PM), differ from pyridoxine (PN) in the respective location of an aldehyde and amine group at the 4 position of the pyridine ring structure (Fig. 1). The 5 -phosphoric ester of pyridoxal, pyridoxal-5 -phosphate (PLP), is the metabolically active form of vitamin Be. Pyridoxamine-5 -phosphate... 

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