3-hydroxy-3-methylglutaryl coenzymeA

Fig. 4 Reconstruction of the carotenoids biosynthetic pathway in S. cerevisiae. Heterologous activities t-HMGl 3 hydroxy-3-methylglutaryl-coenzymeA, ctrE geranylgeranyldiphosphate synthase (from Xanthophyllomyces dendrorhous), Ctrl phytoene desaturase, ctrYB bifunctional enzyme phytoene synthase and lycopene cyclase. Endogenous yeast activities ISIS I geranylgeranyldiphosphate synthase. Metabolites IPP isopentenyl diphosphate, GPP geranyl diphosphate, FPP famesyl-diphosphate, GGPP geranylgeranyl diphosphate...

FIGURE 21-3. Biosynthetic pathway for cholesterol. The rate-limiting enzyme in this pathway is 3-hydroxy-3-methylglutaryl coenzymeA reductase (HMG-CoA reductase). 

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