3-Hydroxy-8-methyldecanoic acid

A strain of B. circulans produces a broad spectrum antibiotic designated as EM 49. This antibiotic is a mixture of closely related lipopeptides which contain five DAB residues out of eight amino acids like the octapeptins. The structure of the peptide moiety of EM 49 is identical with that of octapeptin (Table 8). The fatty acids of EM 49 are 3-hydroxy fatty acids with 10 or 11 carbon atoms. They were identified as 3-hydroxy-8-methylnonanoic acid, 3-hydroxydecanoic acid and 3-hydroxy-8-methyldecanoic acid (752). 

Vinylamycin, a 14-membered cyclodepsi-peptide ( depsipeptides) isolated from the culture broth of Streptomyces sp. (MI982-63F1). Vinylamycin consists of D-valine, alanine, 4-amino-2,4-pentadienoic acid, and 2-hydroxy-3-(2-hydroxyethyl)-4-methyldecanoic acid. It exhibits broad and moderate antimicrobial activities against Gram-positive bacteria [M. Igarashi et al., J. Antibiot. 1999, 52, 873]. 

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