3- Hydroxy-4-methoxyaniline

Problem 19.28 Prepare (a) 2-bromo-4-hydroxytoluene from toluene, (b) 2-hydroxy-5-methylbenzaIdehyde from p-toluidine, (c) m-methoxyaniline from benzenesulfonic acid. M... 

S)-Proline also catalyzed Mannich reactions of ketone donors in a three-component (donor ketone, 4-methoxyaniline, aryaldehyde) protocol, as shown in Table 2.16 [84b, 90, 91]. In these three component reactions, the C-C bond formation occurred at both a-positions of unsymmetrical alkyl ketones (entry 3), and the ratio of the regioisomers depended on the reactant ketones and aldehydes. When the reaction was performed using a ketone donor possessing an a-hydroxy or methoxy group, C-C bond formation occurred exclusively at the oxy-substituted a-carbon (entries 5-7) the major diastereomer was again the syn-product. The enantioselectivities of (S)-proline-catalyzed three-component... 

Me ether see 4 Methoxyaniline, M-00073 Et ether see 4-Ethoxy aniline, E-0005I N- c.- [103-90-2]. 4-Hydroxy acetanilide. 4-Acetamidophenol. F -(4 Hydroxyphenyl)acetamide. Acetaminophen, USAN. Paracetamol, BAN, INN. Panadol. Tramil. Hedex. Numerous proprietary names CgHpNOj M 151.165... 

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