2-Hydroxy-4-methoxy-6 -chloroacetophenone

Methoxy-6-chloro-3-8-acetamidoethylbenzo[ blthiophen, a potential anti-ovulatory agent, was prepared in the usual way via condensation of 3-hydroxy-4-chloroacetophenone with rhodanine followed by ring-closure of the intermediate 2-mercapto-2-butenic... 

Also obtained (by-product) by reaction of zinc powder and silver chloride on 2-hydroxy-4-methoxy-a-chloroacetophenone in benzene and crotonaldehyde mixture at 60-70° [2745],... 

Also obtained from 4-hydroxy-3-methoxy-a-bromoacetophenone [2801] or 4-hydroxy-3-methoxy-a-chloroacetophenone [2802] by rednctive removal of the halogen atom with iron filings and 10% sulfnric acid in aqneons etlianol at 60°. 

Preparation by reaction of sodium iodide on 4-hydroxy-2-11 methoxy-a-chloroacetophenone in acetone at r.t. [4432],... 

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