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Hydroxide-Ion Promoted Hydrolysis of Amides

Amides can also be hydrolyzed when heated under strongly basic conditions. O O [Pg.762]

Hydroxide ion is the nucleophile instead of water. Because it is a better nucleophile than water, it forms the tetrahedral intermediate more rapidly. [Pg.762]

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Amidate ion

Amidation/hydrolysis

Amide ion

Amides hydrolysis

Hydrolysis of amides

Hydroxide ion

Of promotion