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Hydroquinine diether

In 2010, Shibata and co-workers developed an enantioselective enamine-trifluoropyruvate domino aldol-cyclisation reaction to yield chiral pyrroli-dones. Several commercially available derivatives of cinchona alkaloids were screened in combination with Ti(Oi-Pr)4. Hydroquinine diether ((DHQD)2AQN) was found to be the best ligand and afforded the products in high yields and enantioselectivities of up to 92% ee, as shown in Scheme 7.19. Using this system, five cyclic enamines with different protecting groups were screened with remarkable results. The enantiomers of the products were also accessible by applying the pseudoenantiomeric cinchona alkaloid. [Pg.129]

Reagent for Sharpless Asymmetric Dihydroxylation K3Fe(CN)6, K2C03,(DHQD)2-PHAL (=Hydroquinine 1,4-phtalazmediyl diether), K20s02(0H)4 [1500 1500 5 1] Bipyridinium chlorchromate Bridget tetrahydrophosphole Butyllithium... [Pg.353]

See other pages where Hydroquinine diether is mentioned: [Pg.484]    [Pg.234]    [Pg.52]    [Pg.102]    [Pg.99]    [Pg.101]    [Pg.561]    [Pg.471]    [Pg.362]    [Pg.52]    [Pg.199]    [Pg.90]    [Pg.92]    [Pg.488]    [Pg.1796]    [Pg.1830]   
See also in sourсe #XX -- [ Pg.109 ]



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