Hydrophobic ionogenic organic compound distribution

Jafvert, C. T., Westall, J. C., Grieder, E., Schwarzenbach, P. (1990) Distribution of hydrophobic ionogenic organic compounds between octanol and water organic acids. Environ. Sci. Technol. 24, 1795-1803. 

Some highly hydrophobic weak acids and bases exhibit substantial hydro-phobicity even in the ionized state. For highly hydrophobic ionogenic organic compounds, not only is transfer of the neutral species between the aqueous phase and the immiscible phase important, but the transfer of the hydrophobic, ionized, organic species as free ions or ion pairs may also be significant [37]. Mathematically, this is described by refining the n-octanol/ water partition coefficient, as defined in equation (2.7), to reflect the pH-dependent distribution between water (W) and K-octanol (O) of chemical X in both the ionized and nonionized forms. If chemical X is a weak acid, HA, the distribution ratio is... 

For example, the ratio of the n-octanol/watcr distribution coefficient of the nondissociated species to that of the ionic species is nearly 10,000 for 3-methyl-2-nitrophenol, but only about 1000 for pentachlorophenol because of the greater significance of the hydrophobicity of the ionized form of pentachlorophenol. The logarithm of the -octanol/water distribution coefficient of pentachlorophenol as the phenolate is about 2 (determined at pH 12, and 0.1 M KC1), which indicates significant distribution of the ionized form into the n-octanol phase [8,37], Extraction of such highly hydrophobic ionogenic organic compounds can result from mixed-mode mechanisms that incorporate both the hydrophobic and ionic character of the compound. 

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