Hydrophobic and Lyophobic Solvation

As shown by Frank and Evans 41 , solutions of apolar substances in water are characterized by a large entropy of mixing, leading to a high positive free energy of dissolving. 

This effect is explained by a structuring of the solvent surrounding the apolar solute. Table 2 shows a comparison of the thermodynamical excess quantities for mixing the pure solvent with the pure solute to an infinitely diluted solution for hydrophobic and non-hydrophobic solutes, according to Chan et al. 42). 

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