10-Hydroperoxy-4-estren-3,17-dione

The time-dependent inactivation of aromatase by 10-hydroperoxy-4-estrene-3,17-dione, reportedly a mechanism-based inactivator of aromatase -is inhibited by NADPH or an alternative substrate and is partially reversed by dithiothreitol. Other high affinity 10-substituted analogs, such as the mechanism-based inhibitor 10-p-mercaptoestr-... 

The inactivation of AR by the 10/8-hydroperoxy-4-estrene-3,17-dione (92), a steric mimic of the intermediate 19-hydroxy-4-androstene-3,17-dione (19),... 

Covey, D.E., W.F. Hood, D.D. Bensen, and H.L. Carrell (1984). Hydroperoxides as inactivators of aromatase 10-Beta-hydroperoxy-4-estrene-3,17-dione, crystal structure and inactivation characteristics. Biochemistry 23, 5398-5406. 

---