Bradycardia hydromorphone

Due to hydromorphone s potency, numerous adverse effects have been reported. CNS depression is the most frequently reported clinical effect. The typical overdose patient may present with extreme somnolence and may progress to coma. Miosis is usually present unless the individual is acidotic or has suffered hypoxic brain injury. Respiratory depression can occur and may progress to respiratory arrest. Pulmonary edema may be seen. Bradycardia, hypotension, and hyperthermia can develop. Available opiate immunoassays cross-react unreliably with hydromorphone. 

Observational studies In 223 patients who were given intravenous hydromorphone 1 mg followed by an optional 1 mg 15 minutes later, there was oxygen desaturation in 5%, bradycardia in 10%, nausea in 13%, vomiting in 7%, and pruritus in 5% no serious adverse events were reported [Sl ]. 

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