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Propargyl alcohols hydromagnesiation

Hydromagnesiation (11, 163-164 12, 168-169). Cp2TiCl2-catalyzed syn-addition of isobutylmagnesium chloride to propargylic alcohols affords a stereoselective route to vinylmagnesium chlorides for further synthetic use. ... [Pg.120]

HYDROMAGNESIATION REACTION OF PROPARGYLIC ALCOHOLS (E)-3-PENTYL-2-NONENE-1,4-DIOL FROM 2-OCTYN-1-OL... [Pg.106]

Hydromagnesiation butenolides.1 Reaction of optically pure y-trimethylsilyl propargylic alcohols with isobutylmagnesium bromide catalyzed by Cp2TiCl2 (14,... [Pg.116]

Table 3.7. Hydromagnesiation of propargyl alcohols with Grignard reagents... Table 3.7. Hydromagnesiation of propargyl alcohols with Grignard reagents...
Hydromagnesiation followed by carbon-chain extension also serves as a stereoselective preparation of the trisubslituled double bonds frequently found in terpencs. The reaction often works in a complementary manner to the existing methods, which is illustrated in the preparation of (E,Z)-and ( ,f. )-fanicsols (Scheme 3.9) 71.I0I. When the propargyl alcohol was treated with /-BuMgCI... [Pg.266]

In the synthesis of zoapatanol, hydromagne-siation was taken as a viable path to obtain the key intermediate (Scheme 3.11) 188. Thus, the propargyl alcohol was hydromagnesiated in a standard way and the resulting alkenylmage-sium intermediate was quenched with CO2 to give the stcreo-defincd carboxylic acid in 659c... [Pg.267]

See other pages where Propargyl alcohols hydromagnesiation is mentioned: [Pg.125]    [Pg.917]    [Pg.110]    [Pg.334]    [Pg.56]    [Pg.170]    [Pg.85]    [Pg.95]    [Pg.262]    [Pg.264]    [Pg.264]    [Pg.267]    [Pg.31]   


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