Hydrogenolysis Hydrogen peroxide

Hydrogen cyanide reactions catalysts, 6,296 Hydrogen ligands, 2, 689-711 Hydrogenolysis platinum hydride complexes synthesis, 5, 359 Hydrogen peroxide catalytic oxidation, 6, 332, 334 hydrocarbon oxidation iron catalysts, 6, 379 reduction... 

More recently, the same group achieved a simple, highly stereocontrolled total synthesis of (+)-hirsutic acid (Scheme LXXIX) ". This chirally directed effort developed subsequent to reaction of dl-728 with (+)-di-3-pinanylborane, alkaline hydrogen peroxide oxidation, chromatography, PCC oxidation, and hydrogenolysis. The dextrorotatory hydroxy ketone 729 was nicely crafted into keto aldehyde 730 from which 720 was readily obtained. Once again, the Wacker oxidation played an instrumental role in annulation of the third five-membered ring. The remainder of the asymmetric synthesis was completed as before. 

Enantioselective, multiple centers 153, 166,189 Hydroamination Intermolecular Alkene 30 Alkyne 1 Intramolecular Alkene 30 Alkyne 13,170 Hydrogen peroxide Oxidation of alcohols 26, 86 Hydrogenolysis of epoxide 1 Hydrozirconation 32... 

Thus, hydrogen peroxide has found application in the implementation of the well-known organic reactions in the gas phase—dehydrogenation, epoxidation, hydrogenolysis, nitrile formation from /V-alkylbcnzcne, nitrogen fixation, etc. 

The hydrogenolysis of 0-0 linkages is involved in the hydrogenation of peroxides, hydroperoxides, and ozonides. Decomposition may occur catalytically in the absence of hydrogen, as was observed in as early as 1818 by Thenard with hydrogen peroxide in the presence of platinum. 

The treatment of the readily available model cyclopenteno coumarin (d)55) with silver (I) oxide/sodium hydroxide, of thallium (I) ethoxide/hydrogen peroxide, gave fair to good yields of the desired Q, analog (115). [Exhaustive hydrogenolysis of (115), prepared by either method, proceeded by absorption of three equivalents of... 

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