Hydrogenation catalyst, palladinized charcoal

The resulting solution was filtered through animal charcoal and, after addition of 2 liters of methanol, it was debenzylated by hydrogenation at 60°C over palladinized charcoal as a catalyst. After removal of the catalyst by filtration, the filtrate was concentrated by evaporation, whereupon the hydrochloride of 1-p-methoxyphenyl-2-((3-3, 5 -dihydroxyphenyl-(3-oxo)-ethylamino-propane (MP 244°C) crystaiiized out. For the purpose of demethyiation. 

Other olefinic ketones have been reduced selectively at room temperature and atmospheric pressure over a platinum or palladium catalyst to give good yields of the ketones, namely, 5-methyl->heptanone (94%), diisobutyl ketone (100%), and a-benzylacetophenone (81-95%). Selective hydrogenations of some 3-alkyl-2-cyclohexenones have been carried out over palladinized charcoal in essentially quantitative yields. Preparation of platinum catalyst has been described. Many olefinic ketones prepared by the aldol condensation or by acylation of olefins have been hydrogenated however, the yields are not always stated. Benzalacetone, CgHsCHasCHCOCHj, is selectively reduced to benzyl-acetone in a 63% yield by the action of sodium amalgam in acetic acid-alcohol solution. ... 

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