Hydrogenase enzymes, enzyme modeling

Thiolate-bridged dinickel complexes and, in particular, heterobimetallic Ni/Fe complexes have attracted much interest as model systems for the hydrogenase enzymes. A review covering this... 

The metal-free hydrogenase enzyme system was also studied by theoretical calculations.52 This study involved the reactions of two model systems (115 and 116) with molecular hydrogen (Table 3). Cation 115... 

Figure 3 Speculative model for the hydrogenase enzyme cycle such as that from D. gigas. The highest oxidation states of the enzyme are at the top, and each step down corresponds to a one-electron reduction. Some hydrons that are transferred to sites in the protein are not shown. Redox states of the iron-sulfur clusters are omitted.

The chemistry of model systems of hydrogenase enzymes has developed along with the study of the enzymes. Developments in the characterization of the enzyme have spurred the development of model systems that provide a better understanding of the function of the enzyme. Ultimately, a complete understanding of the chemistry of the hydrogenase enzymes will require the synthesis of both areas of study. In this review we consider the work that has been done to characterize the enzyme, focussing on the areas that are amenable for study using model systems. We then... 

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