Hydrogen bonding steric interference with

The various properties of molecules that can be used in a QSAR are often designed to quantitate the tendency of the molecules to participate in one of the fundamental types of intermolecular interactions electrostatic, hydrogen bonding, dispersion forces, and hydrophobic interactions. In addition, the possibility of steric interference with an interaction is considered. Other methods capitalize on the fact that the 2D structure of a molecule indirectly encodes its properties, instead generate descriptors without an explicit relationship to some physical property. 

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