Hydrogels hydrolytically degradable

Sahoo S et al (2008) Hydrolytically degradable hyaluronic acid hydrogels with controlled temporal structures. Biomacromolecules 9(4) 1088-1092... 

Kunioka, M., Choi, H. J. 1998. Hydrolytic degradation and mechanical properties of hydrogels prepared from microbial poly(amino acid)s. Polymer Degradation and Stability 59(1-3) 33-37. 

In this contribution we intend to provide a eomprehensive review on PLA stereo-complex, including preparation, strueture-properties and biomedical applications. The effect of stereo-complex on the thermal dynamics, hydrolytic degradation, micellization and hydrogelation will be discussed. 

Ulbrich, K., V. Subr, P. Podperova and M. Buresova, Synthesis of novel hydrolytically degradable hydrogels for controlled Arussreierise, Journal of Controlled Release, 34 (1995) 155-165. 

The hydrolytic process consists in a cleavage of chemical bonds by the addition of water. The cross-linking density, the local pH, and the polymer network chemistry, including backbone molecular weight, crystallinity and hydrophobicity, influence the degradation rate of hydrolytically degradable hydrogels. 

PLA and its copolymers have several end-use applications. The major applications include short shelf-life products such as plastic bags for carrying household waste, overwrap and lamination films, barriers for sanitary products and diapers, planting, disposable cups and plates, and so on [120]. Hydrolytic degradability of PLA has generated a lot of interest for biomedical applications such as drug delivery systems [134-142], protein encapsulation and delivery [143-145], development of microspheres [146-154], hydrogels [155], bone screws [156], sutures [157-161], scaffolds [162], and so on. However, the unreinforced PLA has certain limitations and that is why a lot of researches have been dedicated to... 

Zustiak, S.P., Leach, J.B. Hydrolytically degradable poly(ethylene glycol) hydrogel scaffolds with tunable degradation and mechanical properties. Biomacromolecules 11, 1348 (2010)... 

Kunioka M (1995), Hydrolytic degradation and biodegradation of hydrogel prepared from microbial poly(e-lysine) , Sen i Gakkaishi, 51(3), 137-142. 

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