Hydroformylation phosphine/phosphite directing group

Functional group-directed hydroformylation. Phosphine and phosphite moieties in olefinic substrates exert strong directing effects on the regioselectivity of hydroformylation. For example, hydroformylation of 4-(diphenylphosphino)-l-butene (32) catalyzed by Rh2(OAc)4/4PPh3 gives branched aldehyde 33, which subsequently is reduced to provide the corresponding alcohol 34 as the sole product (Eq. 16)." Under the same conditions, 1-hexene affords the linear alde-... 

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