Hydroformylation Phosphabarrelene-rhodium

Recently, a new class of phosphabarrelene/rhodium catalysts has been developed, which for the first time allows for hydroformylation of internal alkenes with very high activity and which proceeds essentially free of alkene isomerization [36-38]. Two examples, results of hydroformylation of an acyclic and a cyclic internal alkene substrate, are depicted in Scheme 2. 

A new class of phosphabarrelene/rhodium catalysts was found to display very high activity toward hydroformylation of internal alkenes with unusually low tendency toward alkene isomerization (Equation 7.6) [54]. 

Scheme 2 Position-selective hydroformylation of internal alkenes with a rhodium(I)/-phosphabarrelene catalyst...

A new class of phosphabarrelene (13)-rhodium catalysts was described that allow the hydroformylation of internal alkenes with very high activity and proceed free of alkene isomerization [36]. 

Fuchs E, Keller M, Breit B (2006) Phosphabarrelenes as ligands in rhodium-catalyzed hydroformylation of internal alkenes essentially free of alkene isomerization. Chem Eur J... 

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