Hydroformylation-Deformylation Reaction

Co Ltd) (1982) Patent JP 59112933 Chem. Abstr., 101 (1984) 191213 (b) No Inventor data available (to Mitsubishi Petrochem Co Ltd and Mitsubishi Yuka Fine Chem. Co Ltd.) (1985) Patent JP 60100532 Chem. Abstr., 103 (1985) 196290. 

and Buschken, W (to Oxeno Olefin-chemie GmbH) (2001) Patent DE 19957522 (b) Sigl, M., Poplow, E, 

Inventor not nominated (to Esso Research and Engineering Company) (1964) Patent US 3,127,451. 

(a) McKetta, J.J. Jr., (ed) (1984) Encyclopedia of Chemical Processing and Design, vol. 20, Marcel Dekker, Inc., Madison, WI, p. 382 (b) Chauvel, A. and Lefebvre, G. (eds) (1989) Petrochemical Processes, Institut Frangais du Petrole Publications, Imprimerie Nouvelle, Saint-Jean-de-Braye, pp. 92—94 (c) Weissermel, K. and Arpe, H.-J. (eds) (1997) Industrial Organic Chemistry, VCH Publishers, Weinheim, p. 138. 

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Although iminium cations are usually formed from a secondary amine and an aldehyde, other masked species can also be used in synthesis. Recently, Alper and co-workers reported the synthesis of hexahydropyrrolo[2,l,-6]oxazoles by the Rh-catalyzed hydroformylation of an oxazolidine heterocycle 164 (Scheme 76) with linear selective ligand Xanthphos. This reaction proceeds diastereoselectively through a unique and imexpected silica-mediated (Lewis Acid) hydroformylation-deformylation pathway (139). 

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