Pancuronium Hydrocortisone

Meyers EF. Partial recovery from pancuronium neuromuscular blockade following hydrocortisone administration. Anesthesiology 1977 46(2) 148-50. 

Marked resistance to the effects of pancuronium (but not vecuronium) was seen in one patient receiving an aminophylline infusion. Two other patients are reported to have shown a similar resistance but they had also been given hydrocortisone, which could have had a similar effect (see also Neuromuscular blockers + Corticosteroids , p.l21). These appear to be the only reports of such an interaction. 

These reports contrast with another, in which 25 patients who had no adrenocortical dysfunction or histories of corticosteroid therapy were given pancuronium, metocurine, tubocurarine or vecuronium. They showed no changes in their neuromuscular blockade when given a single intravenous dose of dexamethasone 400 micrograms/kg or hydrocortisone 10 mg/kg. 

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