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Hydrocodone APAP

HYCD/APAP (Watson) Hydrocodone/APAP 36.5 Pain... [Pg.421]

HYCD/APAP (Malinckrodt) Hydrocodone/APAP 19.0 Pain... [Pg.421]

Vicodin ES (apap + hydrocodone bitartrate) 1-2 tabs q4-6h. pm pain... [Pg.66]

APAP with hydrocodone (generic) Alor 51500 (Atley) Hydrocodone ASA... [Pg.335]

Generic Name hydrocodone bitartrate/acetami-nophen (HC/APAP)... [Pg.452]

Hydrocodone has a half-life of 3.8 boms, peak effect at 1.3 hours, and a duration of 4.6 hours. It is metabolized by the liver and excreted primarily in urine. Hydrocodone is oxidized to hydromorphone by cytochrome P450 2D6. The extended-release formulation has measurably different pharmacokinetics following a single dose of 1,2 or 3 HC/ APAP CR tablet(s), the mean maximum plasma concentration (C ) ranged from 13.3 to 36.8 ng/mL for HC and 2.01 to 6.68 ng/mL for APAP. The mean time to reach (T ) was 6.0-6.7 hours for HC and 1.1-1.3 hours for APAP. Following twice-daily dosing of 2 HC/APAP CR tablets for 3 days, steady-state HC/APAP concentrations were attained by 24 hours [3,4]. The mean on day 3 was 37.0 ng/mL for HC and 4.96 ng/mL for APAP. Systemic exposures of HC and APAP demonstrated a dose-proportional increase from one to three tablets. Steady-state concentrations were reached by 24 hours with minimal accumulation following twice-daily administration. Thus, it can be taken every 12 hours [4]. [Pg.452]

Controlled-release HC/APAP is only formulated as an oral preparation containing a standard dose of hydro-morphone 15 mg and acetaminophen 500 mg, to be administered every 12 hours. Phase 3 study data indicate that 12-hour dosing provided effective pain relief for patients with moderate to severe acute and chronic pain. The drug should not be crushed or tampered with as that will change the pharmacokinetics of the extended-release hydrocodone. At this time, the manufacturer has not disclosed whether HC/APAP CR will be manufactured in a tamper-resistant formulation. [Pg.454]

See other pages where Hydrocodone APAP is mentioned: [Pg.34]    [Pg.335]    [Pg.34]    [Pg.335]    [Pg.154]    [Pg.61]    [Pg.423]    [Pg.452]    [Pg.29]    [Pg.21]    [Pg.895]    [Pg.895]    [Pg.897]    [Pg.1205]    [Pg.1205]    [Pg.727]    [Pg.895]    [Pg.895]    [Pg.897]    [Pg.427]    [Pg.453]   
See also in sourсe #XX -- [ Pg.21 ]



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APAP

Hydrocodone

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