Hydride transfer Marcus theory

Marcus theory of a parallel effect on a for hydride transfer reaction between NAD+ analogs. 

Hydride transfers are a very important category of reactions in organic and biological chemistry, and can be a model for electrophilic reactions, because they can be viewed as transfer of a proton with a pair of electrons between electron deficient sites [31], A + BH AH + B+. A large number of theoretical studies have addressed this topic, and the theory of Marcus gives a reasonable representation of the relation between rate and... 

It should be emphasized that the cross relation is not a corollary of current PCET theory and that there is little theoretical justification for applying it (although Marcus has briefly discussed this). Still, the cross relation has been successfully applied to group transfer reactions including proton and hydride transfers,and Sn2 reactions. While these successes are notable, in each instance the cross relation holds only over a narrow set of reactants and reactions. In contrast, the treatment described here has shown to be a powerful predictor for a wide array of HAT reactions. 

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