Hydrazinopyrazines preparative routes

The major preparative routes to hydrazinopyrazines have been covered already by primary synthesis (see Chapters 1 and 2) and by hydrazinolysis of halogenopy-razines (see Sections 4.2.1 and 4.4). Minor routes (like the hydrazinolysis of alkylthio-, alkylsulflnyl-, alkylsulfonyl-, or mercaptopyrazines) appear to be unrepresented in the recent literature. 

The major and recently used preparative routes to azidopyrazines have been covered already by azidolysis of halogenopyrazines (Sections 4.2.6 and 4.4) and by treatment of hydrazinopyrazines with nitrous acid (Section 7.4). In addition, direct C-azidation of pyrazines has been used for example, the lithio intermediate (225), generated in THF by treatment of 2-methoxypyrazine (224) with lithium 2,2,6,6-tetramethylpiperidine, gave 2-azido-3-methoxypyrazine (226) (87%) on subsequent treatment with p-toluenesulfonyl azide.232... 

---

See also in sourсe #XX -- [ ]

See also in sourсe #XX -- [ ]

---