Hydrazino nicotinamide HYNIC

The hydrazino nicotinamide (HYNIC) system (Fig. 11) developed by Abrams and co-workers [106] has been successfully used for preparation of... 

Tc(V) Hydrazino Nicotinamide (HYNIC) Derivatives. The introduction of the Tc(V)-HYNIC system (Schwartz et al. 1991) represents a milestone in the development of Tc-99m radiopharmaceuticals. Particularly, peptides have been labeled with very high specific activity (Edwards et al. 1999 a Harris et al. 1999 Rose et al. 1998). Since the HYNIC linker occupies only one coordination site, coligands such as tricine, ethylenediamine dia-cetic acid (EDDA), etc., may complete the coordination sphere of the metal (Babich et al. 2000 Edwards et al. 1999 b Ono et al. 2000) (Fig. 2.3.4). 

Tc-hydrazino nicotinamide (HYNIC) tricine derivatives with... 

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