Hydrazine substituent, oxidative removal

A -Aryl substituents which are activated by nitro groups can be removed by nucleophilic di.splacement of the triazolyl anion by potassium hydroxide or by hydrazine. Oxidative removal of a p-aminophenyl substituent by potassium permanganate has also been reported. ... [Pg.77]

Hydrazine substituents attached to triazolopyridines undergo normal reactions (for oxidative removal see Section IV, A,3). Treatment with nitrous acid gives an azide216 except in the case of compound 303 when cyclization occurs.16 ... [Pg.143]

The reductive removal of hydrazine substituents under oxidising conditions from azines and some azoles is conceptually related to oxidative removal of thiols (e.g. 29.1.1.2). In this case, the intermediacy of a diimide seems likely, as illustrated below. ... [Pg.577]

The chloro substituent can be removed from 2iS-butyl-3-chloro-5-isobutyl-pyrazine 1 -oxide by heating with hydrazine hydrate at 130° and then treating the... [Pg.152]

One possibility of preparing the parent pyrido[3,4-<7]pyrimidine from the 4-chloro compound uses the conversion into pyrido[3,4-t/]pyrimidine-4-hydrazine and the subsequent removal of the nitrogen substituent by oxidation with mercury(ll) oxide.472... [Pg.194]

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