Hydrates trehalose dihydrate

H26O13, a,a-Trehalose dihydrate, 38B, 441 2H29BrCaOi6f Calcium lactobionate bromide hydrate, 39B, 311 2H3oCaCl20i 5, Bis-(/3-D-f ructopyranose) calcium chloride trihydrate, 40B, 657... 

In situ thermal transitions were also described by Taylor et al., who examined the isothermal dehydration behavior of trehalose dihydrate [29]. For small particle size fractions (<45 fjLm), heating at 80°C caused loss of peak definition until, at 210 min, amorphous material was present. In contrast, a larger particle size fraction (>425 fim) converted to the crystalline anhydrous form of the material. The kinetics of this conversion was probed from the Raman data using peak height ratios with time a two-stage rearrangement was indicated. A broader consideration of pharmaceutical hydrates, including their characterization by several techniques (NMR, Raman spectroscopy, and isothermal calorimetry) can be found in the literature [30] as can a review of the use of spectroscopic techniques for the characterization of polymorphs and hydrates [31]. 

LS Taylor, AC Williams, P York. Particle size dependent molecular rearrangements during the dehydration of trehalose dihydrate—in situ FT-Raman spectroscopy. Pharm Res 15 1207-1214, 1998. RK Khankari, DJW Grant. Pharmaceutical hydrates. Thermochim Acta 248 61-79, 1995. 

---