Hybrid PBPK modeling

Table 6.3 Estimated hybrid PBPK model parameters.

Whereas classical pharmacokinetic models utilize a relatively small number of compartments (see Figure. 6.10), PBPK models seek to mimic physiological pathways and processes controlling the time-course of plasma and tissue concentrations and represent the state-of-the-art in advanced pharmacokinetic systems analysis. Basic concepts of PBPK modeling and a hybrid application to composite nanodevice pharmacokinetics are described in this section. 

Bush ML, Frederick CB, Kimbell JS, et al. 1998. A CFD-PBPK hybrid model for simulating gas and vapor uptake in the rat nose. Toxicol Appl Pharmacol 150 133-145. 

Andersen, M. E., Sarangapani, R., Gentry, P. R., Clewell, H. J. III., Covington, T.R., and Frederick, C. B. (2000). Application of a hybrid CFD-PBPK nasal dosimetry model in an inhalation risk assessment an example with acrylic acid. Toxicol Sci 57, 312—325. 

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