Hybrid PB/PK model

In addition to a large database on lead exposures assembled empirically, a number of biokinetic models to ascertain exposure biomarkers and body lead burdens exist in the more recent lead literature, mainly in the form of such biomarkers of exposure as PbB. These predictive models of systemic lead exposure are of differing complexity and utility in diverse exposure settings. Historically, they can be defined as classical compartment models, a hybrid of the compartmental and physiologically based pharmacokinetic (PB-PK) models or the PB-PK model type. 

---