Hyaluronic acid monomer, effect

Figure 2. Effect of hyaluronic acid on the viscosity of proteoglycan monomer. Concentration of monomer fupper curve 0.1% ("lower curve 0.05%.

Effect of Streptomyces hyaluronidase. The effects of some depolymerizing enzymes on the viscoelastic properties of proteoglycan were examined. The first example was that of Streptomyces hyaluronidase (hyaluronate lyase, EC 4.2.2.1.), which is shown as strictly specific to hyaluronic acid (j6). Thus this enzyme can degrade only the hyaluronic acid backbone of aggregate and should not attack the proteoglycan monomer. To 0.1% solution of aggregate 0.05TRU of Streptomyces hyaluronidase was added. As... 

Effect of chondroitinase ABC. This enzyme (chondroitin ABC lyase, EC A.2.2.A.) also depolymerizes the hyaluronic acid backbone of aggregate. In addition, it can degrade chondroitin sulfate chains of monomer, but not its keratan sulfate chains. 

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