Hurd-Mori cyclisation

The most common, convenient and versatile synthesis of 1,2,3-thiadiazoles is undoubtedly the Hurd-Mori cyclisation of semicarbazones with thionyl chloride. This reaction was again widely reported in the literature during 2000 (e.g. <00ASJC687, 00JHC1325, 00T3933>. 

A versatile synthesis of a series of novel 4-substituted 1,2,3-thiadiazoles 88 not easily obtained by other methods was described by Filippone et al. The final step in the preparation of 88 involved Hurd-Mori cyclisation of a-substituted hydrazones 87 using thionyl chloride at room temperature. Compounds of type 88 were attractive targets due to their potential use in medicinal and agricultural chemistry <01SL557>. 

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See also in sourсe #XX -- [ ]

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