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Huperzine molecular modeling

Camps, R El Achab, R. Gorbig, D. M. Morral, J. Munoz-Torrero, D. Badia, A. Banos, J. E. Vivas, N. M. Barril, X. Orozco, M. Luque, F. J. Synthesis in vitro pharmacology and molecular modeling of very potent tacrine-huperzine A hybrids as acetylcholinesterase inhibitors of potential interest for the treatment of Alzheimer s disease. J. Med. Chem., 1999, 42(17) 3227-3242. [Pg.181]

Several members of a series of hybrid molecules of THA and huperzine-A (279) were more active against acetylcholinesterase than (-)-huperzine-A,but they were not as selective for the enzyme (compared with butyryl-cholinesterase) as huperzine-A (349). Molecular modeling of compounds in the series with acetylcholinesterase from Torpedo californica showed them to interact "as truly THA-huper-zine-A hybrids." However, it was noted that acetylcholinesterase from Torpedo is somewhat different from that of humans. A subsequent paper (350) reported a study of predic-... [Pg.97]

See other pages where Huperzine molecular modeling is mentioned: [Pg.179]    [Pg.97]    [Pg.2055]    [Pg.52]    [Pg.52]    [Pg.595]    [Pg.595]   
See also in sourсe #XX -- [ Pg.52 ]



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