Humans drug interactions

Erhardt PW. A human drug metabolism database potential roles in the quantitative predictions of drug metabolism and metabolism-related drug-drug interactions. Curr Drug Metab 2003 4 411-22. 

Drugs which Independently have little effect on laboratory tests may Interact to produce a significant alteration of test values. Table VII presents several drug Interactions In diabetic human subjects which can affect an apparent test result (15). 

The microorganisms do not necessarily always form the same metabolites as humans in a similar manner, but they can be useful for studies of drug interactions, disposition, etc. [11]. Although there is no correlation between the mammahan and microbial isozymes, the mechanism involved in microorganisms is still unknown, but may be similar to that involved in animals. Additionally, the fungal metabohsm of the compounds is often affected by the concentration, nutritional factors, inducers, and environmental factors [12]. 

Hanai, T., Miyazaki, R., and Kinoshita, T., Quantitative analysis of human serum albumin-drug interactions using reversed phase and ion-exchange liquid chromatography, Anal. Chim. Acta, 378, 77, 1999. 

As far as sinusoidal uptake is concerned, drug-drug interactions have also been reported between antituberculosis agents (rifamycin SV and rifampicin) and bromosulfophthalein in humans both drugs reduce the clearance of bromosul-fophthalein and also induce hyperbilirubinemia [108]. These results may be ac-... 

Shitara, Y., Lu, C., Li, A. P., Y. Kato, Y., Suzuki, H., Ito, K., Itoh, T., Sugiyama, Y., Cryopreserved human hepatocytes as a tool for the prediction of in vivo transport and transporter-mediated drug-drug interactions, Abstract of International Conference on Drug Interaction, Hamamatsu, October 21-23, 1999, p. 87. 

Jones, B. C., Ciark, S. E., Human cytochromes P450 and their role in metabolism based drug-drug interactions, in Drug-Drug Interactions. Rodrigues, A. D. (ed.), 2001, Chapter 3, 55-88. Marcel Dekker Inc. New York. 

Labroo, R. B., Paine, M. F., Thummel, K. E., Kharasch, E. D., Fentanyl metabolism by human hepatic and intestinal cytochrome P4503A4. Implications for interindividual variability in disposition, efficacy and drug interactions, Drug Metab. Disp. 1997, 25, 1072-1080. 

S. V., Evidence for two nonidentical drug-interaction sites in the human P-glycoprotein, Proc. Natl. Acad. Sci. USA 1997, 94, 10594-10599. 

---