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Humanized monoclonal antibodies definition

The immunoglobulin fraction derived from the polyclonal hyperimmune serum of humans and animals has been used clinically in combating conditions such as bacterial infections and maternal immunization by Rh-positive cells from the fetus. Polyclonal sera raised against proteins have also been valuable diagnostic and research tools. However, the undefined composition of polyclonal antisera results in wide and unpredictable cross-reactivities. Furthermore, the quantities of antibody available are limited to the amount of serum an immunized animal can yield. Monoclonal antibodies described below circumvent these problems of definition and quantity associated with polyclonal sera. [Pg.58]

See other pages where Humanized monoclonal antibodies definition is mentioned: [Pg.3]    [Pg.181]    [Pg.3]    [Pg.210]    [Pg.312]    [Pg.18]    [Pg.479]    [Pg.480]    [Pg.62]    [Pg.237]    [Pg.246]    [Pg.25]    [Pg.454]    [Pg.243]    [Pg.533]    [Pg.58]    [Pg.58]   
See also in sourсe #XX -- [ Pg.433 ]



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