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Human thrombin receptor PAR

A THEORETICAL MODEL OF THE HUMAN THROMBIN RECEPTOR (PAR-1), THE FIRST KNOWN PROTEASE-ACTIVATED G-PROTEIN-COUPLED RECEPTOR... [Pg.245]

Overall, our results provide a working hypothesis for the molecular recognition that occurs between the human thrombin receptor (PAR-1) and its agonist peptide SFLLRN. Similar features may contribute to the interactions of the X. laevis homologue of PAR-1 with TFRIFD and of human PAR-2 with SLIGKV, although... [Pg.268]

At this point, we had assembled a preliminary model of the human thrombin receptor that contained all three extracellular loops linked to the seven TM domains, as well as the N-terminus out to residue 75. Docking studies with agonist peptide SFLLRN, and additional mutagenesis experiments, were carried out in parallel. Measurement of the effects of site-specific mutations in human PAR-1 identified several key amino acids of the receptor as being important for activation (Table 1),... [Pg.260]

See other pages where Human thrombin receptor PAR is mentioned: [Pg.247]    [Pg.249]    [Pg.251]    [Pg.253]    [Pg.255]    [Pg.257]    [Pg.259]    [Pg.261]    [Pg.263]    [Pg.265]    [Pg.267]    [Pg.268]    [Pg.269]    [Pg.271]    [Pg.247]    [Pg.249]    [Pg.251]    [Pg.253]    [Pg.255]    [Pg.257]    [Pg.259]    [Pg.261]    [Pg.263]    [Pg.265]    [Pg.267]    [Pg.268]    [Pg.269]    [Pg.271]    [Pg.246]    [Pg.261]    [Pg.261]    [Pg.338]    [Pg.169]    [Pg.1022]    [Pg.249]    [Pg.261]    [Pg.262]    [Pg.169]    [Pg.1022]    [Pg.183]    [Pg.2335]    [Pg.283]    [Pg.550]    [Pg.1020]    [Pg.39]    [Pg.1020]    [Pg.568]   


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Human thrombin

Human thrombin receptor

Thrombin

Thrombin receptor

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